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Joined 1 year ago
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Cake day: February 27th, 2025

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  • One of the medications, atomoxetine, approved by the U.S. Food and Drug Administration (FDA) in 2002 for attention-deficit/hyperactivity disorder, increases levels of the excitatory neurotransmitter norepinephrine by blocking its reuptake (…). In sleep apnea patients, it’s known that the decline of norepinephrine during sleep contributes to a loss of tone among upper airway muscles, particularly the genioglossus. The other compound, called aroxybutynin, is a chemically tweaked form of a drug used to treat overactive bladder. It blocks certain receptors for acetylcholine, preventing this neurotransmitter from inhibiting the nerve that enervates genioglossus—effectively toning up the muscle during sleep.


















  • Well, on the other hand, it’s by far not always the case that the program one person is currently using is already the best choice for their use case. For example, in the process of degoogling, I’ve begun using a lot of programs that are actually better for me than the ones I previously used.

    Of course there’s friction/effort involved in finding the best replacement, but there’s just no way around that if the goal is to get away from the defacto standards.